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酸性可激活上升转换后发光尾酒纳米粒子用于超敏感的体内成像

Yue Jiang¹, Min Zhao¹, Jia Miao¹

¹State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.

Nature communications

|March 8, 2024

概括

新的有机上升转换后发光尾酒纳米粒子 (ALCNs) 提供了改进的"关闭"瘤成像. 它们利用酸度操纵的单片氧转移来提高效率和灵活性,优于传统的光成像.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
医疗成像医学成像

背景情况:

可激活后发光发光纳米探针提供了改进的成像,但面临着局限性.
目前的纳米探针依赖于生物标志物中断的能量传输,需要接近捐赠者-接受者 (<10 nm).
这种近距离要求导致了纳米探针设计和应用的低效率和实际挑战.

研究的目的:

为增强瘤成像开发新的有机上转换光发尾酒纳米粒子 (ALCNs).
在可激活的纳米探测器中克服传统能量传输机制的距离限制.
为了证明ALCNs in vivo对于高信号噪声比的瘤检测的有效性.

主要方法:

合成有机上升转换后发光尾酒纳米粒子 (ALCNs).
使用酸度操纵的单片氧 (1O2) 传输来激活信号,允许更大的捐赠者-接受器距离.
通过实验室酸度激活的发光和小鼠皮下和骨瘤的体内成像来验证ALCNs.

主要成果:

ALCNs证明了高效和灵活的酸度激活后发光发光.
在体内对4T1异体移植的皮下瘤和正型肝脏瘤的成像显示了高的信号与噪声比率.
生物修饰ALCNs (Bio-ALCNs) 在肺转移和皮下瘤成像方面表现出增强的向性,敏感性和特异性.

结论:

ALCNs提供了一种创新和通用的方法,用于可激活的光照影像.
与传统方法相比,酸度操纵的单点氧传递机制提供了更高的效率和灵活性.
ALCNs显示出在瘤成像中具有广泛实用性的潜力,其性能优于光成像.

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