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非编码的自身免疫风险变体定义了ICOS在T外围辅助细胞发育中的作用

Taehyeung Kim1, Marta Martínez-Bonet2,3, Qiang Wang1

  • 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Nature communications
|March 8, 2024
PubMed
概括

一种与风湿性关节炎和1型糖尿病相关的遗传变异增强可诱导T细胞辅助器 (ICOS) 表达,促进外围T助手细胞 (Tph) 发育和自身免疫反应.

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