微量元素水平对心血管疾病和成人2型糖尿病风险的混合作用,使用G计算分析
Borhan Mansouri1, Ayoob Rezaei1, Kiomars Sharafi2
1Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Scientific reports
|March 8, 2024
概括
这项研究揭示了血清中的重金属和必需金属与心血管疾病 (CVD) 和2型糖尿病 (T2D) 有关. 和是心血管疾病风险的关键因素,而,,和与T2D有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
背景情况:
- 人们越来越担心混合污染物暴露对健康的影响.
- 重金属和必需金属是无处不在的环境污染物,具有潜在的不良健康影响.
研究的目的:
- 研究特定重金属/必需金属的血清含量与心血管疾病 (CVD) 和2型糖尿病 (T2D) 风险之间的关联.
主要方法:
- 在Ravansar非传染性疾病 (RaNCD) 队列中,来自450名参与者的血清样本 (150名CVD,150名T2D,150名健康人) 用ICP-MS分析了9种金属.
- 使用后勤回归和量子G计算 (QGC) 来评估单金属和多金属暴露风险,并对共变量进行调整.
主要成果:
- 血清中的,和含量与心血管疾病风险有显著的相关性.
- ,和铜水平显示与T2D风险有关.
- 重量四分位数总和 (WQS) 指数表明CVD和T2D都有显著的关联,其中 (Cd), (Pb) 和 (Ni) 是高度加权的贡献者.
结论:
- 特定有毒和必需元素的血清水平在患心血管疾病和T2D的风险中起着重要作用.
- 和似乎是心血管疾病风险的主要驱动因素,而Pb,Ni,Cr和Cd与T2D风险有关.
- 建议进行进一步的大规模前性研究,以验证这些发现并确定额外的贡献因素.
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