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Yifei Lu1, Deqian Chen1, Bingnan Wang2

  • 1Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai, 201102, China.

Oncogene
|March 8, 2024
PubMed
概括

不差异化的多形肉瘤 (UPS) 呈现出显著的内异质性,起源于介质干细胞 (MSC). 向表皮生长因子受体 (EGFR) 显示出对这种侵袭性软组织癌症的治疗潜力.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...