针对儿科和成人AML的先天免疫系统
Alicia Perzolli1,2, Joost B Koedijk1,2, C Michel Zwaan1,2
1Princess Máxima Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands.
Leukemia
|March 8, 2024
概括
针对急性髓性白血病 (AML) 的免疫疗法有限. 了解与生俱来的免疫系统.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 基于T细胞的免疫疗法在许多癌症中表现有前途,但急性髓性白血病 (AML) 的进展缓慢.
- 针对AML的有效免疫疗法需要了解免疫抑制瘤微环境 (TME) 并确定合适的向抗原.
- 目前在AML中的免疫特征主要集中在T细胞上,忽略了像单细胞,粒细胞和自然杀手 (NK) 细胞这样的先天免疫细胞.
研究的目的:
- 审查AML TME内先天性免疫组的当前知识.
- 讨论针对先天性免疫细胞以增强AML免疫疗法的潜力.
- 突出需要深入描述AML的先天免疫力.
主要方法:
- 关于AML和固体癌症的先天免疫力的现有研究的文献综述.
- 在TME中分析先天免疫细胞的可塑性和功能状态.
- 综合有关先天性免疫细胞在调节抗瘤反应中的作用的信息.
主要成果:
- 固体癌症中的先天性免疫细胞 (巨细胞,骨髓原抑制细胞,中性粒细胞) 是可塑的,可以采用免疫抑制的表型.
- 固体癌症中的自然杀手 (NK) 细胞通常表现出功能受损.
- 在AML TME中先天性免疫细胞的作用和特征是不太了解的,但对于治疗开发至关重要.
结论:
- 对AML的先天性免疫组的全面了解对于设计有效的免疫疗法至关重要.
- 准先天性免疫细胞有可能改善基于T细胞和其他免疫治疗策略的AML.
- 迫切需要对AML的先天免疫格局进行进一步的研究,以指导临床干预.
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