维生素D与SUN项目的2型糖尿病发病风险:前性队列研究
A Valer-Martinez1,2, C Sayon-Orea3,4,5,6, J A Martinez7,8
1Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
Journal of endocrinological investigation
|March 8, 2024
概括
较高的维生素D水平与患2型糖尿病 (T2D) 的风险较低有关. 这项在地中海人口中进行的研究发现了显著的反向关联,支持维生素D.
科学领域:
- 营养流行病学 营养流行病学
- 代谢性疾病研究研究.
- 公共卫生营养 公共卫生营养
背景情况:
- 维生素D缺乏与慢性疾病有关,包括胰岛素抵抗和2型糖尿病 (T2D) 等代谢障碍.
- 了解维生素D在T2D预防中的作用对于公共卫生战略至关重要.
- 地中海人口有独特的饮食模式,可能会影响维生素D状态和T2D风险.
研究的目的:
- 调查预测血清维生素D水平与T2D发病率之间的关联.
- 在一个大规模的,有前景的地中海成年人群中分析这种关系.
- 提供维生素D在这个人口群体中对T2D预防的潜在作用的证据.
主要方法:
- 利用了SUN项目,一个未来的西班牙大学毕业生队列.
- 使用经过验证的食物频率问卷来评估饮食摄入量并预测血清维生素D状态.
- 应用考克斯回归模型,调整混因子,分析维生素D四分位数与T2D风险之间的关联.
主要成果:
- 包括18,594名参与者,平均随访时间为13.5年 (238,078人年).
- 在随访期间观察到209例T2D事件病例.
- 发现了显著的反向关联:更高的预测维生素D水平 (Q4与Q1) 与2型糖尿病风险降低52%有关 (HR:0.48,95% CI 0.26-0.88;p趋势=0.032).
结论:
- 在基线预测较高的血清维生素D水平与患T2D的风险降低有关.
- 这些发现表明,维生素D在T2D预防中具有潜在的保护作用.
- 进一步的研究可以探索地中海人群中代谢健康的最佳维生素D水平.
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