葡萄糖皮质类药物在代谢功能障碍相关的脂肪性肝病中的作用
Stergios A Polyzos1, Giovanni Targher2,3
1First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. spolyzos@auth.gr.
Current obesity reports
|March 8, 2024
概括
葡萄糖皮质类药物可以通过增加胰岛素耐药性和肝脏脂肪积累,使代谢功能障碍相关的脂肪性肝病 (MASLD) 恶化. 尽量减少葡萄糖皮质激素的使用和抑制11β-HSD1表明对管理MASLD有希望.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学 是一个学科.
背景情况:
- 葡萄糖皮质类药物广泛用于炎症和自身免疫性疾病.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 葡萄糖皮质体和MASLD之间的相互作用越来越被认可.
研究的目的:
- 审查使用葡萄糖皮质体和MASLD之间的关联.
- 探索链接葡萄糖皮质体和MASLD的病理生理机制.
- 讨论MASLD患者在葡萄糖皮质类药物治疗中的治疗影响.
主要方法:
- 系统审查已公布的数据.
- 对临床前和临床证据的分析.
- 专注于生化和生理途径.
主要成果:
- 葡萄糖皮质类药物可以诱导高血糖,高胰岛素和胰岛素抵抗,这是MASLD病变的关键.
- 葡萄糖皮质类药物通过增加脂解和de novo脂生成,促进肝脏脂肪的积累,同时降低脂肪酸氧化.
- 有证据表明,葡萄糖皮质类药物可能会加剧肝炎和纤维化.
- 11β-基类固醇脱酶1型 (11β-HSD1) 和5α-减少酶是这一协会中的关键酶.
结论:
- 葡萄糖皮质类药物与MASLD病理生理学密切相关.
- 在患有MASLD的患者中,最大限度地降低葡萄糖皮质醇剂量至关重要.
- 对11β-HSD1的药理抑制表明了对MASLD的治疗潜力.
相关概念视频
Overview of Carbohydrate Metabolism
1.0K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.0K
Overview of Lipid Metabolism
1.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.5K
Liver Physiology
546
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
546
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
118
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
118
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Hormones Regulating Blood Glucose
3.3K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.3K


