IL-18在脂肪组织重塑和代谢功能障碍中的作用
Jaqueline Pereira Lana1, Marina Chaves de Oliveira1, Ana Letícia Malheiros Silveira1
1Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
International journal of obesity (2005)
|March 8, 2024
概括
介素-18 (IL-18) 缺乏导致肥胖和葡萄糖不耐受性在小鼠. IL-18信号可能调节脂肪组织扩张和新陈代谢,这表明对IL-18的抵抗可能会使肥胖症中的葡萄糖控制恶化.
科学领域:
- 代谢研究的研究.
- 免疫学 免疫学 免疫学
- 肥胖研究的研究.
背景情况:
- 肥胖与脂肪组织中益炎性细胞因子的增加有关.
- 介素-18 (IL-18) 显示出对肥胖和代谢功能障碍的保护作用.
研究的目的:
- 研究IL-18在调节脂肪组织重塑和新陈代谢中的作用.
- 了解IL-18缺乏对代谢健康的影响.
主要方法:
- 使用C57BL/6野生型和IL-18缺乏的小鼠在食中.
- 分析了减肥手术患者的脂肪组织和体内组织样本.
主要成果:
- 缺乏IL-18的小鼠表现出增加的脂肪,炎症和葡萄糖不耐受.
- IL-18是由肌体血管分量分泌的,而不是脂肪细胞,并且独立于骨髓影响脂肪膨胀.
- 当IL-18来自骨髓细胞时,它保持葡萄糖平衡.
- 在肥胖人群中,IL-18表达与代谢标记物如IRS1,GLUT-4,阿迪波内克丁和PPARy负相关.
结论:
- 对于控制脂肪组织扩张和葡萄糖代谢而言,IL-18信号传递似乎至关重要.
- 缺少IL-18会导致小鼠的自发肥胖和葡萄糖不耐受.
- 对IL-18信号的抵抗可能与人类肥胖的葡萄糖代谢受损有关.
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