获得FDA批准的化学抗原受体 (CAR) - - 针对不同癌症的T细胞疗法 - - 最近的前景.
R Thirumalaisamy1, S Vasuki2, S M Sindhu2,3
1Department of Biotechnology, Sona College Arts and Science, Salem (Dt.), Tamil Nadu, 636005, India. tmalaisamy@gmail.com.
Molecular biotechnology
|March 8, 2024
概括
化学抗原受体-T (CAR-T) 细胞疗法为各种癌症提供了新的治疗选择,解决了日益增长的全球健康挑战. 这篇评论探讨了CAR-T疗法.
科学领域:
- 瘤学和免疫学
- 生物技术和基因工程 生物技术和基因工程
背景情况:
- 全球癌症发病率正在上升,这对公众健康构成了重大挑战.
- 化学抗原受体-T (CAR-T) 细胞疗法是一个有前途的新型治疗方式.
- 低收入和中等收入国家 (LMICs) 受癌症的影响不成比例,与联合国可持续发展目标3保持一致.
研究的目的:
- 审查各种癌症的新型化学抗原受体-T (CAR-T) 细胞疗法治疗选择.
- 讨论CAR-T细胞治疗在癌症治疗中的分子机制,优点和优势.
- 为利用CAR-T细胞协议提供洞察力,用于患者复苏和潜在的疾病根除.
主要方法:
- 对各种癌症的CAR-T细胞治疗进行了全面的文献搜索.
- 搜索的数据库:谷歌学者,科学直接和PubMed.
- 纳入标准:2000年1月至2023年12月间发表的文章;48篇符合条件的论文,从18700篇中选出.
主要成果:
- 卡特-T细胞疗法在治疗各种癌症类型方面显示出显著的潜力.
- 分析了CAR-T细胞在癌症治疗中的有效性背后的详细分子机制.
- 该综述强调了CAR-T细胞疗法的优势,改善了患者的治疗结果和生存率.
结论:
- 卡特-T细胞疗法是一个快速发展的领域,对各种恶性瘤有很大的前景.
- 进一步研究和应用CAR-T细胞协议可以改善癌症患者的寿命.
- 这种疗法有可能使疾病复发,在某些情况下甚至可以根除疾病.
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