关于大脑周脉空间数量和位置与认知功能之间的关系的元分析
Ling Liu1, Liangdan Tu1, Qiuyan Shen1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
概括
大脑周血管空间的增加与认知能力下降有关. 它们的位置和相关条件影响哪些认知功能受到影响最大,影响大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 大脑周血管空间 (CPS) 是大脑微血管系统的组成部分,有助于废物清除和淋巴排水.
- CPS特征 (数量,位置) 与认知功能之间的确切关系在很大程度上仍未定义.
研究的目的:
- 进行全面的元分析,调查大脑周脉空间的严重程度和位置与认知表现之间的关联.
- 综合现有研究数据,以澄清CPS对各种认知领域的影响.
主要方法:
- 在PubMed,EMBASE,Web of Science和Cochrane控制试验中心注册表 (2000年1月 - 2023年7月) 进行系统的文献搜索.
- 对28项涉及7908名参与者的研究 (26项截面,2项纵向) 的数据进行了元分析.
- 通过使用可用的调整方法,在不同大脑区域比较跨领域的认知表现与CPS严重程度,使用可用的调整手段. 在PROSPERO注册的协议 (CRD42023443460).
主要成果:
- 较高的基底腺 CPS 与降低的一般智力和注意力相关.
- 增加中心半形CPS与较差的一般智力,执行功能,语言和记忆相关.
- 升高的海马CPS与增强的记忆力和执行功能有关. 亚组分析表明基于潜在疾病条件的变化.
结论:
- 更多的脑周血管空间与认知障碍有关.
- CPS和共存疾病状态的特定位置显著调节对不同认知领域的影响.
相关概念视频
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:11Cerebrum: Anatomical Overview II
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
01:31Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
01:05Cerebral Hemispheres
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
01:22Lobes of the Cerebrum
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements.
01:28Lateralization
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.