皮质-囊的功能障碍:系统性审查
1Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Medical Center, New York, New York.
Diseases of the colon and rectum
|March 9, 2024
概括
伊利奥囊 (IPAA) 手术可以帮助患者,但会改变正常功能. 目前的研究往往忽略了解剖学和生理学变化,限制了对囊功能障碍和患者症状的理解.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 患者的治疗结果.
背景情况:
- 囊门外科手术 (IPAA) 是一种常见的手术,需要进行直肠切除术的患者.
- 该手术涉及解剖学和生理学妥协,影响正常排便和囊功能.
- 患者经常经历各种症状,需要清楚地了解其原因,以便有效管理.
研究的目的:
- 为了审查与ileoanal pouches相关的症状.
- 讨论这些症状的可能原因.
- 为了澄清关于囊功能和功能障碍的文献.
主要方法:
- 在PubMed和Cochrane数据库中搜索了1983年至2023年间发表的关于"ileoanal pouch功能"和"ileoanal pouch功能障碍"的研究.
- 审查了553篇关于功能和178篇关于功能障碍的文章,不包括案例研究,重复和特定疾病的文章.
- 专注于术后的定义,症状评分和预期的生理变化.
主要成果:
- 审查了27项关于功能障碍和38项关于功能障碍的研究.
- 很少有研究 (3) 定义了正常的囊功能,而其他研究则尝试测量 (10) 或评分 (4).
- 只有3项研究专门讨论了袋子生理学.
结论:
- 了解皮囊功能障碍是由于缺乏研究皮囊形成的解剖和生理后果而受到阻碍.
- 现有的研究往往无法解释修复性直肠切除术后改变的排便生理学,限制了口袋功能的解释.
- 需要进一步的研究来充分阐明IPAA手术后的囊功能和功能障碍.
相关概念视频
01:21Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145
01:17Chronic Bowel Disorders: Introduction
450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
01:17Irritable Bowel Syndrome I: Introduction
273
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
273
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
184
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
184
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
160
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
160
01:17Drugs for Treatment of Diarrhea-Predominant IBS
169
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
169