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在移植患者的爱斯坦-巴尔病毒相关性结肠炎:一个案例系列
Ana Catarina Brás1, Sara Querido2, André Mascarenhas3
1Nephrology Department, Hospital Prof. Dr. Fernando Fonseca, Amadora, Portugal.
Infectious diseases (London, England)
|March 9, 2024
概括
爱斯坦-巴尔病毒 (EBV) 可以在移植 (KT) 患者中引起大肠炎,经常出现严重的胃肠道症状. 诊断需要多学科的方法,尽管治疗,结果可能很差.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 胃肠道并发症在移植 (KT) 接受者中是常见的,原因是免疫抑制.
- 在KT患者中结肠炎的差异诊断包括免疫抑制剂不耐受,新发炎性肠病 (IBD) 和机会性感染.
- 爱斯坦-巴尔病毒 (EBV) 是一个未被认可的造成移植后结肠炎或新发性IBD的原因.
研究的目的:
- 详细介绍三个患有EBV相关性结肠炎的移植患者的临床特征,诊断结果,治疗方法和结果.
- 为了突出诊断和治疗这种罕见并发症的挑战.
主要方法:
- 对三个被诊断患有EBV相关性结肠炎的移植患者的回顾性分析.
- 收集的数据包括移植史,胃肠道症状,内镜和组织学发现以及随访信息.
- 排除大肠炎的其他潜在原因,如细胞巨化病毒,酸菌酸莫菲蒂尔不耐受,淋巴增殖性疾病和移植对宿主疾病.
主要成果:
- 三名患者的病例系列 (平均年龄59岁),在KT.后5-22年出现EBV大肠炎.
- 症状包括血淋淋的腹,腹痛,体重减轻和发烧.
- 两名患者经历了不利的结果,包括死亡,尽管免疫抑制剂修改,抗病毒疗法,IVIG和手术.
结论:
- 多学科的方法对于及时诊断EBV相关的大肠炎在移植接受者至关重要.
- 长期监测和开发有效,安全的疗法对于管理这种罕见的疾病至关重要.
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