在瘤微环境中,LncRNAs 作为巨细胞的调节器
Kangning Li1,2, Tao Xie1, Yong Li3
1The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, China.
Carcinogenesis
|March 9, 2024
概括
长非编码RNAs (lncRNAs) 通过影响瘤相关巨细胞 (TAMs) 来调节瘤的发展. 这些lncRNAs促进TAM招募和M2极化,支持癌症的进展.
科学领域:
- 分子生物学分子生物学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 长非编码RNAs (lncRNAs) 是细胞功能的关键调节者,包括基因表达和蛋白质调节.
- 与瘤相关的巨细胞 (TAMs),特别是M2极化的巨细胞,在瘤开始,血管生成,转移和免疫逃避中至关重要.
- 在瘤微环境 (TME) 中高TAM透与癌症预后不佳相关.
研究的目的:
- 审查lncRNAs在调节巨细胞招募,两极分化和瘤微环境中的功能方面的多方面的作用.
- 阐明TAM和瘤细胞内的lncRNA如何影响TAM行为并促进癌症进展.
主要方法:
- 在各种癌症类型中对lncRNAs和TAMs的最新研究的文献综述.
- 分析 lncRNAs 影响巨细胞两极分化和功能的机制.
- 检查 lncRNA 参与 TAM 招募和透到 TME 的情况.
主要成果:
- 在TAMs中的lncRNAs直接调节细胞过程.
- 含有lncRNAs的瘤衍生外体诱导巨细胞的M2样极化.
- 瘤细胞中的lncRNAs有助于释放TAM调节因子,促进TAM招募和M2极化.
结论:
- lncRNAs通过控制TAM行为,在塑造瘤微环境方面发挥着重要作用.
- 针对参与TAM调制的lncRNAs,为癌症治疗提供了一个潜在的治疗策略.
- 对lncRNA-TAM相互作用的进一步研究对于理解和对抗癌症进展至关重要.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K