Pseudostellaria heterophylla通过调节小鼠肠道微生物群和代谢物来改善肠道微生态
Shengkai Zhang1, Tao Kang2, Antonino Malacrinò3
1Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Journal of the science of food and agriculture
|March 9, 2024
概括
Pseudostellaria heterophylla通过促进有益的细菌和免疫因子,同时减少病原体,提高肠道健康. 这种传统中医药通过其代谢产物有望改善肠道微生物群和宿主健康.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- Pseudostellaria heterophylla是一种传统的中医药,具有已知的免疫调节和抗氧化特性.
- 它在调节肠道微生态中的特定作用在很大程度上仍未被探索.
- 这项研究调查了P. heterophylla对免疫功能和肠道微生物群的影响.
研究的目的:
- 为了阐明Pseudostellaria heterophylla对宿主免疫功能的影响.
- 评估P. heterophylla调节肠道微生物群和代谢组的能力.
- 探索P. heterophylla在维持肠道健康方面的治疗潜力.
主要方法:
- 评估免疫因子,红细胞和小鼠的血小板计数在循环胺诱导的损伤下.
- 使用16S rRNA测序分析肠道细菌群体的多样性和组成.
- 进行代谢分析,以确定微生物代谢物的变化.
- 绘制细菌宿主共同代谢途径的地图.
主要成果:
- 施用P. heterophylla增加了红细胞,总抗氧化能力和免疫因素,同时降低了血小板数量.
- 观察到肠道微生物群的显著变化,包括有益细菌 (Akkermansia,Roseburia) 的增加和病原体 (Cupriavidus,Staphylococcus) 的减少.
- 代谢分析显示功能性寡糖类,维生素和功能性物质的水平升高,影响了11种细菌宿主共同代谢途径.
结论:
- Pseudostellaria heterophylla有效地促进益生菌的丰富性,并减少肠道中的致病细菌.
- 草药刺激宿主微生物产生有益的二次代谢物,有助于宿主健康.
- 这些发现凸显了P. heterophylla在肠道健康中的作用及其作为功能性食品成分的潜力.
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