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Updated: Jul 1, 2025

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

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洞察纳二烯合成酶催化和随性,由可变性景观和分子动态促进的随性

Siqi He1, Ingy I Abdallah1,2, Ronald van Merkerk1

  • 1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Planta
|March 9, 2024
PubMed
概括

这项研究使用蛋白质建模和模拟来研究抗癌性Taxol生物合成中至关重要的taxadiene合成酶 (TXS). 突变特定残留物揭示了对酶乱交的洞察力和对工程Taxol生产的潜力.

关键词:
阿尔法折叠模型模型催化活动是催化活动.变异发生的突变.产品简介 产品简介类化物 类化物

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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD108:17

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
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