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Updated: Jul 1, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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发现了SQSTM1/p62依赖的P体,这些P体调节NLRP3炎症体

Elizabeth R Barrow1, Evelina Valionyte1, Chris R Baxter1

  • 1Peninsula Medical School, Faculty of Health, University of Plymouth, Research Way, PL6 8BU Plymouth, UK.

Cell reports
|March 9, 2024
PubMed
概括

在细胞应激下,自的p62滴转化为扩大的P体 (pd-PBs). 这些pd-PBs招募ASC来激活NLRP3炎症体,导致炎症和细胞毒性.

关键词:
在 ASC/PYCARD 中.科普:分子生物学 分子生物学这就是LLPS.在NLRP3炎症酶体中,NLRP3炎症在P体中,P体是P体.这些是RNP颗粒.在SQSTM1/p62中使用.自自是自的过程.液态-液态相隔离方法 液态相隔离方法压力颗粒是压力颗粒.

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