在lnc-HLX-2-7,HLX和MYC之间有一个可针对治疗的正反循环,该循环促进3组髓母细胞瘤
Keisuke Katsushima1, Kandarp Joshi1, Menglang Yuan1
1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD 21231, USA; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL 33701, USA.
Cell reports
|March 9, 2024
概括
一种新发现的长非编码RNA, lnc-HLX-2-7,驱动了第三组脑髓母细胞瘤 (G3 MB) 的进展. 用纳米颗粒准这种RNA显著抑制瘤生长并提高生存率.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症发展中的作用.
- 第三组髓母细胞瘤 (G3 MB) 是一种具有有限治疗选择的侵袭性儿科脑瘤.
研究的目的:
- 研究lnc-HLX-2-7在G3 MB病原发生中的作用.
- 评估lnc-HLX-2-7作为G3 MB的潜在治疗点.
主要方法:
- 用RNA测序和染色质免疫沉来识别和描述lnc-HLX-2-7调节通路.
- 在体内研究中使用了内G3 MB异种移植小鼠模型,用氧化物-纳米粒子涂层的反感性寡核化物 (CNP-lnc-HLX-2-7) 进行治疗.
主要成果:
- 发现 lnc-HLX-2-7 通过招募增强元件来激活 HLX 瘤基因.
- HLX被证明可以激活关键瘤基因,包括MYC,LIN9,TBX2和HOXM1.
- 在小鼠模型中,CNP-lnc-HLX-2-7治疗减少了40%-50%的瘤生长.
- 与CNP-lnc-HLX-2-7和西斯普拉丁联合治疗显著改善了生存率.
结论:
- lnc-HLX-2-7-HLX-MYC轴是G3 MB进展的一个关键调节器.
- lnc-HLX-2-7代表了G3 MB的有前途的治疗标.
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Hedgehog Signaling Pathway
7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K


