孕期糖尿病女性的血清可佩:一个元分析
Yuanqi He1, Xue Li1, Xiaoxiao Li1
1Department of Obstetrics, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, China.
Biomolecules & biomedicine
|March 9, 2024
概括
妊娠期糖尿病 (GDM) 的孕妇和没有妊娠期糖尿病 (GDM) 的孕妇之间,血清中可佩的水平没有显著差异. 然而,高平素水平可能表明女性的GDM风险,身体质量指数 (BMI) 为26kg/m2或更高.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症.
- 之前关于血清可佩和GDM风险的研究已经产生了不一致的结果.
- 科佩是阿尔金因压素的标记物,已被研究其在代谢调节中的作用.
研究的目的:
- 综合评估血清可佩水平与发展GDM风险之间的关联.
- 为了解决关于可佩和GDM的先前研究中的不一致性.
- 在这种关系中调查潜在的缓和因素,例如身体质量指数 (BMI).
主要方法:
- 观察性研究的系统审查和元分析.
- 在Medline,Web of Science,Embase,Wanfang和CNKI数据库中搜索到2023年10月15日.
- 包括10项研究,包括625例GDM病例和1212例对照,使用随机效应模型.
主要成果:
- 总体而言,在患有和没有GDM的女性之间,血清中可佩水平没有显著差异 (SMD 0.01,95% CI -0.22至0.24).
- 在参与者BMI和GDM结果之间观察到正相关性 (系数 = 0.11,P = 0.002).
- 亚组分析显示,GDM女性BMI≥26kg/m2 (SMD0.31,95%CI0.05至0.57) 的可佩含量显著更高,但BMI<26kg/m2的女性没有.
结论:
- 血清可佩和GDM风险之间的关联受到母亲的BMI的显著影响.
- 血清可佩的升高可能是GDM风险的潜在指标,特别是在体重指数为26公斤/平方米或更高的孕妇中.
- 需要进一步的研究来阐明素在GDM病理生理学中的确切作用,特别是在与肥胖有关的方面.
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