推进速度对Tessari方法中的泡稳定性的影响
Sajjad Azmoun1, Yiran Liu2, Kai Bian1
1Department of Plastic and Burn Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
概括
实现稳定的硬化泡需要最佳的特萨里方法技术. 在10秒内执行20次推,最大限度地提高泡的稳定性和压力,这对于有效的硬化疗法至关重要.
科学领域:
- 血管外科 血管外科
- 医疗设备工程 医疗设备工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 泰萨里方法是产生用于硬化疗法的硬化泡的标准技术.
- 泡的稳定性对于硬化疗法治疗的临床有效性至关重要.
- 许多因素影响着硬化剂泡的稳定性,需要优化制备方法.
研究的目的:
- 为了确定Tessari方法的最佳推进速率,以提高硬化泡的稳定性.
- 为了研究在Polidocanol泡制剂中推进持续时间和泡稳定性之间的关系.
主要方法:
- 使用Polydocanol (POL) 溶液 (1%和3%) 通过Tessari方法制备了硬化剂泡.
- 通过在不同时间段 (10-40秒) 执行20个注射器通道来产生泡.
- 用泡半衰期 (FHT) 量化泡稳定性,并测量注射器压力.
主要成果:
- 泡半衰期 (FHT) 减少,当推力持续时间超过20秒1%的POL和15秒3%的POL.
- 在10秒内完成20次推的组中观察到最高的FHT和最佳压力.
- 推速度较慢 (持续时间较长) 导致泡稳定性降低.
结论:
- 建议在10秒内完成20个来回通道,以获得最佳的硬化剂泡稳定性.
- 更快的制备速度提高了泡的稳定性,这对于成功的硬化疗法结果至关重要.
- 该研究提供了基于证据的建议,以改进Tessari方法用于产生泡.
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