定义领域:在OMERACT核心成果集中为基础领域开发基于共识的定义
Lara J Maxwell1, Caitlin Jones2, Clifton O Bingham3
1Faculty of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Centre for Practice Changing Research, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
Seminars in arthritis and rheumatism
|March 9, 2024
概括
研究人员为风湿病学结果测量 (OMERACT) 研究定义了五个核心领域,提高了风湿病学研究的一致性. 全球患者评估需要进一步调查标准化定义.
科学领域:
- 类风湿病学 类风湿病学
- 研究成果 研究成果 研究成果
- 测量科学 测量科学 测量科学
背景情况:
- 风湿病学的结果测量 (OMERACT) 使用临床试验的核心领域集.
- 标准化定义对于统一的数据收集和解读在风湿病研究结果中至关重要.
研究的目的:
- 在OMERACT核心域集中为基础域开发详细的,基于共识的定义.
- 提高风湿病学研究中使用的结果指标的清晰度和一致性.
主要方法:
- 从现有文献和组织指南中系统地识别候选域定义.
- 对OMERACT工作组,患者研究合作伙伴和技术咨询小组进行的双轮Delphi调查.
- 在OMERACT 2023方法论研讨会上使用实践经验建立共识的讨论和定义的上下文化.
主要成果:
- 在五个基本领域的详细定义上达成共识:疼痛强度,疼痛干扰,身体功能,疲劳和与健康有关的生活质量.
- 无法确定患者整体评估的首选定义,这表明需要进一步研究.
- 实践经验的例子被纳入,以对最终定义的域定义进行上下文化.
结论:
- 基于共识的方法成功为五个关键的OMERACT领域提供了详细的定义.
- 这些标准化定义旨在简化仪器选择过程,并减少对未来OMERACT核心成果集开发的资源需求.
- 需要进行进一步的研究,以建立患者全球评估的共识定义.
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