高剂量维生素C对缺血-再输液损伤的作用
Seo Hee Ko1, Ji Hae Jun2, Ju Eun Oh2
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-Gu, Seoul 03722, the Republic of Korea; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-Gu, Seoul 03722, the Republic of Korea.
概括
在再注射期间服用高剂量的维生素C有效地减少心脏手术后的急性损伤,通过减轻氧化应激和炎症. 这种保护作用的最佳剂量是200mg/kg.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管外科心血管外科
- 生物化学 生物化学
背景情况:
- 急性损伤 (AKI) 是心脏手术后的常见并发症,通常是由缺血-再输液 (I/R) 损伤和全身炎症引起的.
- 抗氧化剂,如维生素C,在重症患者中耗尽,可能对氧化应激产生治疗效益.
研究的目的:
- 研究高剂量维生素C在心脏手术后预防脏I/R损伤方面的疗效.
- 确定维生素C的最佳时间和剂量,以减轻AKI.
主要方法:
- 一项两阶段的Sprague-Dawley大鼠进行脏I/R (45分钟缺血,24小时再输) 的研究.
- 组包括假药,I/R +盐水和维生素C在200mg/kg的I/R前或后给药.
- 剂量范围实验 (100,200,300毫克/公斤) 在最佳时间进行.
主要成果:
- 与缺血前的管理相比,维生素C的缺血后再注射管理显著减少了功能障碍和管道损伤.
- 维生素C (100和200毫克/公斤) 在再注射期间降低了氧化应激标志物 (髓氧化酶) 和炎症 (HMGB1,NLRP3炎症体).
- 200 mg/kg剂量显示出最显著的益处;300 mg/kg剂量在功能和组织学方面没有提供额外的优势.
结论:
- 在再注射期间服用高剂量的维生素C是一种有前途的策略,可以减轻心脏手术后的缺血-再注射损伤.
- 确定的最佳保护剂量为200mg/kg,有效地减少了导致AKI的关键氧化和炎症途径.
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