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可激活GSH的异构三元纳米前药物,用于TNBC的精确协同治疗

Xiaojing Zhang¹, Yansong Chen¹, Jingwei Tang¹

¹Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|March 9, 2024

概括

一个新的纳米粒子系统精确地在三阴性乳腺癌 (TNBC) 治疗中以最佳比例提供多塞塔克塞尔和黄素. 这种协同方法增强了瘤抑制,为组合化疗提供了一个新的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

三重阴性乳腺癌 (TNBC) 治疗从最佳药物比率的组合化疗中获益.
目前的策略缺乏精确控制药物负载和释放比率的协同效应.

研究的目的:

开发一种对谷氨 (GSH) 敏感的异构三元原药,以纳米颗粒 (DSSC2 NPs) 为准确的TNBC协同化疗.
为了实现多塞 (DTX) 和黄素 (CUR) 在特定的协同作用比率 (1: 2) 的可控同时递送.

主要方法:

合成了DTX和CUR的异构三元原药,通过二硫化键连接在一起.
用一种两性聚合物配制前药,以创建DSSC2NP.
评估药物负载,释放动力学,体稳定性和体外/体内治疗疗效.

主要成果:

DSSC2 NPs显示了定量化药物加载,高共同加载能力,增强的稳定性和减少过早泄漏.
在瘤中选择性地积累NP,并在预定义的1:2比率下以GSH触发的方式释放DTX和CUR.
在TNBC模型中通过比度递送和同步药物激活,证明了显著的协同性瘤抑制.

结论:

开发的异构三元原药纳米颗粒为TNBC中精确组合化疗提供了一个新且有效的平台.
相对度药物递送和同步激活是增强协同治疗效果的关键.
这种方法有望改善TNBC治疗结果.

关键词:

组合疗法是一种联合疗法.不变的药物比率是常数.具有GSH响应性的药物负载的比率计.瘤活动向瘤活动向

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