一个结构化的口服化疗教学工具,以提高成年人多发性骨髓瘤的坚持:一个试点随机对照试验
Imran Haider1, Gregory R Pond2, Ruthanne Cameron2
1Royal College of Surgeons in Ireland, Dublin, Ireland.
Journal of geriatric oncology
|March 9, 2024
概括
一项试点研究发现,在使用口服治疗的多发性骨髓瘤 (MM) 患者中,药物坚持率低于最佳水平. 多国癌症支持性护理协会口服药物教学工具 (MOATT) 与标准护理相比,没有改善坚持.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 患者坚持的研究研究.
背景情况:
- 较新的多发性骨髓瘤 (MM) 治疗方法通常是口服的,这带来了坚持挑战.
- 优化口服抗髓瘤治疗的坚持对于治疗疗效至关重要.
- 有限的数据存在于有效的策略,以改善MM患者的药物坚持.
研究的目的:
- 评估跨国癌症支持护理协会口服药物教学工具 (MOATT) 的可行性和有效性,以改善药物服药.
- 为了比较MOATT干预与在开始口服抗髓瘤治疗的患者的标准护理教学.
- 评估干预对患者满意度和药物管理中的自我有效性的影响.
主要方法:
- 一项试点随机对照试验,涉及47名新诊断或复发多发性骨髓瘤患者.
- 患者接受了标准护理教学或MOATT结构化的教学工具.
- 通过使用药物事件监测系统 (MEMS) 帽子在六个月内电子监测依从性.
主要成果:
- 六个月的平均坚持率为86.9%,其中43.9%的患者被归类为不坚持 (坚持率<90%).
- 在MOATT组 (85.6%) 和标准护理组 (87.9%) 之间没有观察到遵守率的显著差异.
- 两组之间,癌症治疗的满意度和药物管理的自我有效性是相似的.
结论:
- 在这项试点研究中,没有发现MOATT工具是可行的或可以接受的.
- 无论是MOATT还是标准护理教学都没有显著改善药物坚持,满意度或自我有效性.
- 未来的研究需要确定有效的教育干预措施和战略,以优化多发性骨髓瘤患者的药物坚持.
相关概念视频
Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
200
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
200
Drug Administration and Therapy Phases: Overview
462
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
462
Nursing Ethical Principles II
965
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
965
Drug Therapy
43
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
43
Clinical Trials: Overview
2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K


