明亮的日光对夜行大鼠的情感和认知结果产生负面影响
James T Sangma1, Zothanmawii Renthlei1, Amit K Trivedi1
1Department of Zoology, Mizoram University, Aizawl, Mizoram 796004, India.
Journal of photochemistry and photobiology. B, Biology
|March 9, 2024
概括
暴露在明亮光线下会损害夜间动物的记忆和认知能力,影响关键的大脑基因表达. 这项研究强调了光周期如何影响这些动物的学习和神经通路.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 动物行为 动物行为
背景情况:
- 每天的光/黑暗周期会影响动物的认知,日光不足与白天活动的物种的情绪和认知缺陷有关.
- 暴露于光线对夜间动物的记忆,学习和认知的影响在很大程度上仍未得到研究.
研究的目的:
- 调查日间变化的光照度和恒定的光照对夜间动物的记忆,学习和认知的影响.
- 分析暴露于光线对关键基因的mRNA表达的影响,这些基因与神经可塑性和海马体,丘陵体和皮质中的功能有关.
主要方法:
- 进行了两项实验:实验1将老鼠暴露在不同的光强度 (10,100,1000lx) 下,在12L:12D循环下进行30天.
- 实验2在恒定的明亮光 (250 lx) 或12L:12D循环下养大鼠4个月.
- 行为测试评估了记忆和认知,随后对包括Bdnf,Trk,miR132,Ng,Gap-43,Crebp,Gsk3β和Tnf-α在内的基因进行了mRNA表达分析.
主要成果:
- 暴露于明亮的日光 (100和1000 lux) 和恒定的光线显著损害了老鼠的记忆,学习和认知功能.
- 在暴露于更高光强度或恒定光线的老鼠的海马体,皮质和乳头体内观察到关键神经可塑性和功能相关基因的抑制mRNA表达水平.
- 这些发现表明,过度暴露于光线对夜间动物的认知过程和神经基因表达有有害影响.
结论:
- 暴露于明亮光线对夜间动物的记忆,学习和认知有负面影响.
- 关键大脑区域的基因表达变化表明,存在潜在的光诱导认知缺陷的分子机制.
- 光对不同的动物群体有着独特的影响,这强调了在研究和环境管理中对特定物种的光循环考虑的重要性.
更多相关视频
05:23Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
3.8K
06:16An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
Published on: February 2, 2022
2.4K
相关概念视频
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:13Insufficient Sleep and Sleep Deprivation
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...