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Updated: Jul 1, 2025

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基于近距离标记的直角陷策略识别HDAC8通过调节皮质素乙化调节促进细胞运动

Yepei Huang1, Guijin Zhai2, Yun Fu3

  • 1The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin 300070, China; Laboratory of Biochemistry and Molecular Biology Research, Department of Clinical Laboratory, Fujian Medical University Cancer Hospital, No. 420 Fuma Road, Jin'an District, Fuzhou 350014, Fujian Province, China.

Cell chemical biology
|March 9, 2024
PubMed
概括

一种新的方法,基于近距离标记的正角陷 (ProLORT),捕捉了细胞中短暂的酶后翻译修饰 (PTM) 相互作用. 这种方法确定了新的HDAC8基质,揭示了细胞运动调节的机制.

关键词:
在 HDAC8 中,HDAC8 是细胞的移动性激发了细胞的运动.酶-基质相互作用lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine lysine一个直角的陷.接近性标签的标签.

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