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Updated: Jul 1, 2025

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
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活体活化激活GCN2通路会在代谢过程中重编程T细胞,从而提高采用细胞疗法的效果

Michael St Paul1, Samuel D Saibil1, Meghan Kates1

  • 1Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada.

Cell reports. Medicine
|March 9, 2024
PubMed
概括

使用halofuginone激活CD8+T细胞中的氨基酸饥饿反应,可以增强它们的新陈代谢和抗瘤活性. 这种方法对癌症免疫治疗有希望,即使在耐药模型中也是如此.

关键词:
在 4-1BBBB 中.CD8 (((+) T细胞是T细胞中的一个.在 GCN2 中.哈洛基诺胺是一种环氧基.采用细胞疗法 细胞疗法自自是自的过程.免疫代谢的免疫代谢.免疫疗法 免疫疗法

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