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Updated: Jul 1, 2025

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

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FKBP5甲基化与情绪调节大脑电路的多模式关联

Thomas L Kremer¹, Junfang Chen², Anais Buhl²

¹Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; DZPG (German Center for Mental Health), partner site Mannheim/Heidelberg/Ulm, Germany.

Biological psychiatry

|March 9, 2024

概括

这种基因是FKBP5基因.

科学领域:

翻译神经科学是一种神经科学.
分子精神病学分子精神病学
神经表观遗传学神经表观遗传学

背景情况:

情绪调节和应激反应的个体差异对于理解精神疾病至关重要.
FKBP5基因是涉及精神疾病的分子压力信号的关键调节者.
在日常应激反应中,FKBP5 DNA 甲基化与神经结构/功能之间的关系尚不清楚.

研究的目的:

为了研究FKBP5DNA甲基化的多式相关物.
检查FKBP5DNA甲基化与神经结构和功能之间的关联.
探索这些关联与日常生活压力反应的相关性.

主要方法:

结合表观遗传数据 (FKBP5 DNA 甲基化) 与神经成像 (MRI) 和门诊评估.
在情绪处理任务中利用功能磁共振成像 (fMRI).
雇佣生态瞬间评估 (EMA) 用于在395名健康个体中测量日常压力因素.

主要成果:

精神病风险因素FKBP5脱甲基化与腹中前额叶皮质 (vmPFC) 灰质体积减少相关,与焦虑有关.
血液中的FKBP5DNA甲基化显示,在情绪处理过程中,前额外边缘回路的功能差异与相关.
这些神经差异预测了对日常压力因素的情感反应,这是EMA测量的.

结论:

FKBP5 DNA 甲基化影响在前额外边缘回路内的神经结构和功能的个体间差异.
这些与FKBP5相关的神经变化影响现实生活,影响调节和应激反应.
这项研究阐明了连接表观遗传学,大脑电路和对压力的行为反应的机制.

关键词:

健行诊断的评估方式表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.在FKBP5中使用.前额叶皮层前额叶皮层.压力压力压力压力

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