与乳相关的疾病:应该检测谁?
Fabiana Zingone1, Julio C Bai2, Christophe Cellier3
1Department of Surgery, Oncology, and Gastroenterology, University of Padua, Padua, Italy; Gastroenterology Unit, Azienda Ospedale-Università Padova, Padua, Italy.
Gastroenterology
|March 9, 2024
概括
对于那些患有自身免疫性疾病,胃肠道疾病或特定遗传综合征的人来说,建议进行乳病 (CeD) 查. 在高风险群体中进行积极的血清检测是识别未诊断的CeD病例的关键.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 乳病 (CeD) 是一种由在遗传敏感个体中引发的免疫媒介疾病,影响大约1%的人口.
- CeD的呈现是多样化的,并且经常被低估,这突显了需要改进诊断策略的需要.
- 在高风险群体中通过血清检测进行主动病例发现是识别未诊断的CeD的最有效方法.
研究的目的:
- 审查最近关于CeD与20多种其他疾病之间关联的证据.
- 在特定患者群体中制定CeD查的建议.
- 为临床医生指导关于疑似CeD的适当诊断步骤.
主要方法:
- 对最近证据的综合文献综述,这些证据将CeD与各种疾病联系起来.
- 对关联的分析,以确定CeD的高患病率和高风险群体.
- 根据审查的证据制定查建议.
主要成果:
- 对于患有自身免疫性疾病,模仿自身免疫性疾病的疾病 (例如,IBS,IBD) 和患有高度自身免疫性疾病的疾病 (例如,一级亲属,1型糖尿病,自身免疫性甲状腺疾病) 的人士,建议对CeD进行查.
- 需要对 CeD 进行查的具体情况包括皮肤炎形性皮肤炎,无法解释的动力衰竭,IgA 缺乏以及某些遗传综合征,如唐氏综合征.
- 血清检测是建议的初始查步骤,在高危患者的上部内镜检查期间建议进行活检.
结论:
- 在确定的高风险群体中进行系统的CeD查对于早期诊断和管理至关重要.
- 将CeD查整合到相关疾病的检查中可以改善患者的治疗结果.
- 医生应考虑在患有广泛的症状和并发症的患者中进行CeD.
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