L1细胞粘附分子 (L1CAM) 表达和分子变化区分低级瘤细胞瘤与异性染色体性细胞癌
Mohammed Alghamdi1, Jie-Fu Chen2, Achim Jungbluth2
1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
概括
脏低度瘤细胞瘤 (LOT) 是一个与异性染色恐惧性细胞癌 (E-chRCC) 不同的实体,在临床,组织学和分子形状上有所不同. L1CAM表达有助于区分LOT,表明主要细胞起源并支持将名称更改为瘤细胞主要细胞腺瘤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 脏低度瘤细胞瘤 (LOT) 是最近分类的脏瘤.
- 形态重叠与异性染色恐惧性细胞癌 (E-chRCC) 创造了诊断挑战.
- 关于LOT独特的临床病理学,免疫组织化学和分子特征的数据有限.
研究的目的:
- 描述和比较LOT和E-chRCC的大队伍.
- 为了确定LOT和E-chRCC之间的区分特征.
- 探索LOT的来源细胞并提出修订后的命名法.
主要方法:
- 67个LOT和69个E-chRCC案件的比较分析.
- 组织学和免疫组织化学 (L1CAM) 评估.
- 分子分析 (TSC-mTORC1路径突变,染色体异常) 和超结构分析.
主要成果:
- LOT主要影响女性,而E-chRCC影响男性.
- LOT显示了一个小型嵌套模式;E-chRCC展示了固体/管状架构.
- 87%的LOT病例具有TSC-mTORC1通路突变;E-chRCC缺乏这些,并且具有典型的chRCC染色体损失.
- L1CAM是LOT的敏感和特异性标记,表明主要的细胞来源.
结论:
- 与E-chRCC相比,LOT是一个独特的实体,具有独特的临床,组织学和分子特征.
- 对于将LOT与E-chRCC区分开来,L1CAM免疫组织化学是至关重要的.
- 拟议的名称变更为"瘤主要细胞瘤"反映了其起源和良性过程.
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