改善VRE控制的营养策略
Enrico Morello1, Sara Roversi2, Giulia Brambilla1
1Department of Clinical and Experimental Sciences, University of Brescia, Bone Marrow Transplant Unit, ASST-Spedali Civili di Brescia, Brescia, Italy.
Transplantation and cellular therapy
|March 9, 2024
概括
实施无乳糖饮食显著降低了细胞治疗患者的抗万科素肠球菌 (VRE) 殖民. 这种营养干预对高风险单位来说是有希望的,可能会降低VRE率和相关并发症.
科学领域:
- 传染性疾病 传染性疾病
- 营养科学 营养科学
- 血液学 血液学 血液学
背景情况:
- 抗胺素抗性肠球菌 (VRE) 构成重大风险,包括增加发病率,死亡率和成本,特别是对于细胞疗法接受者.
- 乳糖消费与肠球菌生长和移植与宿主疾病 (GVHD) 有关,这凸显了饮食修改的必要性.
- 在骨髓移植 (BMT) 单位内的直肠拭子中观察到较高的VRE阳性率.
研究的目的:
- 评估无乳糖饮食对在接受细胞治疗的患者中减少VRE殖民化的影响.
- 评估针对高风险患者群体的乳糖摄入量的营养策略的可行性和有效性.
主要方法:
- 实施了营养干预措施,包括引入无乳糖牛奶和严格遵守无乳糖饮食.
- 为了进行比较,患者被分为乳糖组和无乳糖组.
- 截至2023年6月,直肠拭子中的VRE阳性率被监测到2023年6月.
主要成果:
- 与乳糖组 (16%) 相比,无乳糖组的VRE阳性率显著较低 (3.6%).
- 营养策略表明,在BMT单位内,VRE载体的数量大幅减少.
结论:
- 没有乳糖的饮食策略有效地减少了细胞疗法接受者的VRE殖民.
- 这种干预措施显示出在高风险环境中应用的潜力,如 BMT 和重症监护室.
- 实施无乳糖饮食可能有助于减少VRE隔离,并减少VRE殖民的不必要的抗生素使用.
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