孕期和儿童神经发育结果中的甲福明:系统性审查和元分析
Hannah G Gordon1, Jessica A Atkinson1, Stephen Tong1
1Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
American journal of obstetrics and gynecology
|March 9, 2024
概括
孕妇在怀孕期间使用甲福明并没有与14岁以下儿童的神经发育不良结果相关. 这一发现为孕妇和临床医生提供了关于甲福明安全性的保证.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在怀孕期间,梅特福林经常被处方用于诸如妊娠期糖尿病等疾病.
- 人们担心在子宫内暴露于甲福明的潜在长期神经发育影响.
- 综合证据对于为临床实践和患者咨询提供信息至关重要.
研究的目的:
- 系统地审查和综合有关母亲在怀孕期间使用甲胺和后代神经发育结果之间的相关证据.
- 评估产前甲福明暴露对儿童认知,运动和一般神经发育轨迹的影响.
主要方法:
- 在MEDLINE,Embase和Web of Science (核心集合) 进行了全面的文献搜索,截至2023年7月.
- 包括的研究是随机对照试验,病例对照,队列和横截面设计与后代神经发育数据.
- 数据提取和偏差风险评估由两位审查员独立使用既有工具进行.
主要成果:
- 包括七项具有低偏差风险的高质量研究,包括14042名儿童.
- 母亲使用甲福明并没有与婴儿或幼儿时期的神经发育延迟有关.
- 在14岁之前,与改变的运动或认知得分没有发现任何显著的关联.
结论:
- 在子宫内对甲福明的暴露似乎与儿童的神经发育不良结果无关.
- 这些发现支持在怀孕期间使用甲素对儿童神经发育的安全性.
- 为临床医生和考虑接受甲福明治疗的孕妇提供了保证.
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