产前大麻使用与后代先天性出生缺陷之间的关联:累积的元分析
Abay Woday Tadesse1, Getinet Ayano2, Berihun Assefa Dachew2
1School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA 6102, Australia; Samara University, College of Medicine and Health Sciences, Department of Public Health, 132, Semera, Ethiopia; Dream Science and Technology College, 1466 Dessie, Ethiopia.
Neurotoxicology and teratology
|March 9, 2024
概括
母亲产前使用大麻与新生儿各种结构性出生缺陷的风险增加有关. 建议加强预孕咨询,以减轻这些风险.
科学领域:
- 生殖健康 生殖健康
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 产前大麻使用变得越来越普遍,引发了对胎儿发育潜在不良影响的担忧.
- 了解孕妇在怀孕期间吸食大麻与结构性出生缺陷之间的关联对于公共卫生至关重要.
- 现有研究提出了不同的发现,需要对证据进行全面的综合.
研究的目的:
- 系统地评估和量化产前大麻暴露与后代出生结构缺陷风险之间的关联.
- 提供强有力的证据,为临床实践和公共卫生建议提供有关怀孕期间使用大麻的信息.
主要方法:
- 在多个数据库 (PubMed/Medline,CINHAL,EMBASE,Web of Science,ProQuest,Psych-Info,Google Scholar) 进行了系统的文献搜索,截至2024年1月.
- 包括36项观察性研究 (18个病例控制,18个队列),涉及超过23万例出生缺陷和1800万对照.
- 进行了一项元分析,包括子组,灵敏度和元回归分析,以评估聚合效应估计.
主要成果:
- 产前大麻暴露与多种结构性出生缺陷的风险显著增加有关.
- 对心血管/心脏缺陷 (OR=2.35),胃肠道缺陷 (OR=2.42),中枢神经系统缺陷 (OR=2.87) 和泌尿生殖系统缺陷 (OR=2.39) 观察到特定的风险增加.
- 对于任何未分类的出生缺陷 (OR=1.25),也发现了显著的关联.
结论:
- 孕产妇在产前接触大麻与后代患各种结构性出生缺陷的风险明显增加有关.
- 这些发现突出了预防策略的必要性,包括加强预孕咨询,以解决怀孕期间使用大麻的问题.
- 减轻出生缺陷的风险需要积极的公共卫生干预措施和改善患者教育.
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