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Updated: Jul 1, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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与癌症相关的多基-1基4误解变异可变地影响基连接体结合和细胞生长抑制

Karina L Bursch1, Christopher J Goetz2, Guanming Jiao3

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

The Journal of biological chemistry
|March 9, 2024
PubMed
概括

癌症相关的PBRM1基因的第四个原蛋白 (PBRM1-BD4) 突变会影响蛋白质稳定性和基因素结合. 了解这些PBRM1变异为癌症机制和个性化医学提供了洞察力.

关键词:
类域名 类域名癌症生物学 癌症生物学癌症突变 癌症突变染色体重塑 染色体重塑 的方法表观遗传学是指表观遗传学.功能 功能 功能 功能 功能基因组学就是基因组学.基因素乙化 基因素乙化 基因素乙化蛋白质的稳定性 蛋白质的稳定性在位点导向的突变发生.结构的结构结构的结构.

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