在整个eGFR范围内的癌症结果中的性别差异
Richard Shemilt1,2, Michael K Sullivan1,3, Peter Hanlon4
1NHS Greater Glasgow and Clyde, G12 0XH, UK.
概括
慢性病 (CKD) 患者估计膜过率 (eGFR) 较低,生存率降低,死亡率更高,特别是女性. 较低的eGFR与特定部位的晚期癌症有关,但不广泛.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 与癌症发病率和死亡率的增加有关.
- 估计的淋巴细胞过率 (eGFR) 与晚期癌症呈现,全因死亡率和潜在的性别差异之间的关系需要研究.
研究的目的:
- 检查eGFR的变化是否会影响晚期癌症诊断的可能性.
- 为了确定eGFR是否影响癌症患者的全因死亡率.
- 探索这些协会中潜在的基于性别的差异.
主要方法:
- 使用了来自安全匿名信息链接数据库 (2011-2017年) 的数据.
- 包括新确诊癌症和两次诊断前eGFR测量的人.
- 对于晚期癌症的几率,采用了后勤回归和死亡风险的考克斯比例危险模型.
主要成果:
- 较低的EGFR (<30毫升/分钟/1.73米2) 与晚期前列腺癌,乳腺癌和女性生殖器官癌症的更高几率相关.
- 与eGFR>75-90相比,eGFR<30与男性和女性的全因死亡风险显著增加有关.
- 这种死亡率相关性在女性 (HR 1.71) 比男性 (HR 0.88男性与女性比较) 显著更强.
结论:
- 虽然较低或较高的eGFR在大多数地点都不能一致预测晚期癌症,但它与较差的生存率有关.
- 低EGFR与女性全因死亡率的扩大关联需要进一步调查.
- 研究结果强调了功能,癌症进展和生存结果之间的复杂相互作用,并考虑了性别特异性.
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