在前列腺特异性抗原 (PSA) 查时代,减少死亡率和累积多余发病率 (CEI)
Patrick W McLaughlin1,2, Matthew M Cousins3,4, Alex Tsodikov5
1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Scientific reports
|March 9, 2024
概括
前列腺特异性抗原 (PSA) 查显著降低了前列腺癌死亡率. 这项研究发现,增加查强度与大幅降低死亡率相关,在美国挽救了30多万人的生命.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 前列腺特异性抗原 (PSA) 查对美国前列腺癌死亡率降低的影响仍在争论中.
- 了解查强度和死亡率结果之间的关系对于公共卫生政策至关重要.
研究的目的:
- 评估PSA查强度与前列腺癌死亡率降低之间的关联.
- 为了澄清PSA查时代中种族对这种关系的影响.
主要方法:
- 利用了美国监测,流行病学和最终结果 (SEER) 计划数据 (1980-2016).
- 分析了来自9个登记处的数据,覆盖了9%的美国人口 (163,982,733人年).
- 作为PSA查强度的替代品,就业累计超额发病率 (CEI).
主要成果:
- 在CEI和前列腺癌死亡率之间观察到强烈的反向线性关系.
- 据估计,避免了大约317,356例前列腺癌死亡.
- 美国8个地区的前列腺癌死亡率降低了46.0-63.7%.
- 少数群体,特别是黑人男性,死亡率显著下降.
结论:
- PSA查强度与前列腺癌死亡率的降低密切相关,独立于其他因素.
- 与查利用率相比,治疗方面的进步起到了很小的作用.
- 大规模的PSA查已经带来了相当大的死亡率益处,特别是在少数群体中.
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