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Updated: Jul 1, 2025

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TERRA-LSD1相位分离促进R-循环的形成,以维持ALT癌细胞中的端粒

Meng Xu1, Dulmi Senanayaka2, Rongwei Zhao1

  • 1Department of Biology, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.

Nature communications
|March 9, 2024
PubMed
概括

端粒重复含有RNA (TERRA) 与氨酸特异性脱甲基酶1A (LSD1) 相互作用,促进端粒 (ALT) 途径的替代延长. LSD1-TERRA阶段分离增强了ALT中的R循环形成和端粒维护.

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