与肠道微生物组和代谢组变化相关的阿罗尼亚汁耐受性的个体间差异 - - 一个随机的安慰剂控制的并行干预试验的二次分析
Sonja Lackner1, Alexander Mahnert2, Christine Moissl-Eichinger2,3
1Division of Immunology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Stiftingtalstraße 6, 8010, Graz, Austria.
Microbiome
|March 9, 2024
概括
女性对阿罗尼亚果汁的耐受性与肠道微生物组的变化有关. 对多的个体反应突出了对健康益处的个性化剂量策略的需要.
科学领域:
- 营养科学 营养科学
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 阿罗尼亚 (Aronia melanocarpa) 含有丰富的有益健康的多,但生物利用率和味道各不相同.
- 个人对汁的耐受性有很大差异,这表明了潜在的生物机制.
- 肠道微生物组在食物消化中的作用需要对其与阿罗尼亚果汁耐受性的关联进行研究.
研究的目的:
- 调查健康女性的汁耐受性是否与肠道微生物群的变化有关.
- 探索对阿罗尼亚多耐受性和代谢结果的潜在机制性见解.
- 分析汁对细菌代谢物和肠道微生物群多样性的影响.
主要方法:
- 一项为期6周的随机化安慰剂对照试验 (NCT05432362) 的二次分析,涉及40名女性.
- 干预组每天两次接受阿罗尼亚果汁 (verum,V) 或安慰剂 (P).
- 通过16S rRNA测序分析肠道微生物群多样性;使用MICOM和NMR代谢学分析代谢物.
主要成果:
- 在那些报告抱怨 (Vc) 的人群中,肠道微生物群的多样性保持不变,但在那些耐受良好的人群中 (Vt) 有显著变化.
- 鉴定出明显的微生物衍生代谢物:二氧化碳,氨和O-甘氨在Vc;胆酸在Vt.
- 血NMR代谢学表明,干预后在体组中,脂蛋白子类 (LDL,VLDL) 增加,在洗后恢复.
结论:
- 阿罗尼亚的多醇耐受性与肠道微生物群衍生代谢物有关,影响脂蛋白概况和粘膜肠道健康.
- 结果强调了个性化激素剂量的重要性,以优化多的益处.
- 对汁的动态肠道微生物群反应强调了对多干预的个性化方法的需要.
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