患有原发性性结肠炎的患者的临床和亚托皮特征:一项意大利多中心研究
Carlo Maria Rossi1,2, Marco Vincenzo Lenti1,2, Stefania Merli2
1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
Internal and emergency medicine
|March 10, 2024
概括
乙性结肠炎 (EC) 是一种罕见的胃肠道疾病,通常表现为模糊的症状,导致诊断延迟. 识别女性的过敏原敏感性和特定症状可以帮助早期EC诊断.
科学领域:
- 胃肠病学 胃肠病学
- 过敏和免疫学 过敏和免疫学
- 内部医学 内部医学
背景情况:
- 生性结肠炎 (EC) 是最罕见的初级生性胃肠道疾病 (EGID),由于非特异性临床表现,经常被诊断不足.
- 了解EC的临床特征,亚托皮特征和诊断挑战对于改善患者的治疗结果至关重要.
研究的目的:
- 调查成年EC患者的临床和亚托皮特征.
- 确定诊断延迟和与EC复发相关的因素.
- 为了比较EC特征与乙酸性食道炎 (EoE) 和刺激性肠综合征 (IBS).
主要方法:
- 从40名EC患者的临床,病原体和实验室数据的回顾性分析.
- 与12名EoE和21名IBS患者的年龄匹配队列进行比较.
- 过敏测试包括皮肤刺伤测试和血清特异性IgE;诊断延迟被评估.
主要成果:
- 患者 (平均年龄39岁) 主要是女性 (67.5%),有高的形 (77.5%),腹痛/腹 (70%) 和腹 (77.5%).
- 与EoE不同的是,在EC中,血中乙酸氨基不升高. 在25%的EC患者中发现过敏原敏感性.
- 对于EC,诊断延迟的中位数为10个月,受亚托皮,体重减轻和先前误诊的影响.
结论:
- 结核病往往是一种排除的诊断,具有显著的诊断延迟,特别是在女性患者中.
- 像过敏原敏感化,腹部症状和便calprotectin升高等特征应该引起对EC的怀疑.
- 这些因素的早期识别可能会缩短异性结肠炎的诊断延迟.
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