训练有素和老年人的肌肉纤维大小和肌核定位
Edmund Battey1,2,3, Yotam Levy1, Ross D Pollock1
1Centre for Human & Applied Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
定期的耐力运动可以保护肌肉纤维大小和肌肉核域 (MNDs) 随着衰老. 不活动导致肌肉纤维变小,肌肉核参数发生变化,强调运动.
科学领域:
- 骨肌肉生理学 骨肌肉生理学
- 细胞生物学 细胞生物学
- 衰老的研究研究.
背景情况:
- 肌核架构和定位随着运动和衰老而发生变化.
- 关于运动后肌核数量和定位的现有数据不一致.
- 衰老对多核域 (MND) 和定位的影响尚未得到充分理解.
研究的目的:
- 为了研究年龄,身体活动状态,myonuclear领域和myonuclear定位之间的关系.
- 为了比较年轻和年长的耐力训练的个体与年龄相匹配的未经训练的个体的肌肉核参数.
主要方法:
- 分析了来自四个群体的大侧肌肉活检:年轻训练 (YT),老训练 (OT),年轻未训练 (YU) 和老未训练 (OU).
- 从串行光学z切片进行的肌肉核和肌肉纤维尺寸的三维重建.
- 肌肉纤维横截面积 (CSA),多核数,多核域 (MND) 和多核排列在不同组的比较.
主要成果:
- 与年轻的未受过训练 (YU) 个体相比,老年未受过训练 (OU) 个体的肌肉纤维CSA显着较小 (33%-53%),核与纤维CSA比率更高 (90%).
- 在未经训练的老年人中,MND体积和纤维大小之间的缩放关系发生了变化.
- 肌肉纤维CSA和大多数myonuclear参数与未受过训练的个体的年龄有关,但与训练的个体无关.
- 在所有组中,myonuclear的排列仍然相似.
结论:
- 在一生中定期进行耐力运动可以保持肌肉纤维大小和纤维大小与MND体积之间的关系.
- 不活动与肌肉纤维大小的减少和变化的肌核参数有关.
- 耐力训练可以在细胞水平上减轻骨肌肉与年龄相关的变化.
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