多发性硬化症中的视觉唤起潜力:P100延迟和视觉通路损伤,包括侧面生殖细胞核
Athina Papadopoulou1, Armanda Pfister2, Charidimos Tsagkas3
1Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Switzerland; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland.
概括
在多发性硬化症 (MS) 中,视觉唤起潜力 (VEP) P100延迟与整个视觉通路的损伤有关. 在患有视神经炎 (ON) 的患者中,侧面生殖细胞核 (LGN) 损伤也会影响 VEP P100 延迟.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 是一种影响中枢神经系统的脱髓化疾病.
- 视觉通路损伤在MS中很常见,影响视觉唤起潜力 (VEP).
- VEP的P100组件反映了视觉通路的完整性.
研究的目的:
- 调查VEP中的P100延迟与MS患者的前和后歇斯底里损伤之间的关系.
- 为了识别与P100延迟相关的特定解剖结构.
主要方法:
- 在31名多发性硬化患者和31名对照组中进行了VEP,光学连贯性断层扫描 (OCT) 和MRI.
- 研究人员测试了P100潜伏和周围皮状视网膜神经纤维层 (pRNFL),状细胞/内状层 (GCIPL),侧面生殖细胞核 (LGN) 体积,光学辐射白质病变 (OR-WML),非损伤光学辐射小分异质 (NAOR-FA) 和初级视觉皮层 (V1) 厚度之间的关联.
- 使用边际R平方 (mR2) 量化效应大小.
主要成果:
- 与对照人群相比,多发性硬化患者在P100延迟,prnfl,GCIPL和LGN方面表现出显著差异.
- P100延迟与GCIPL (mR2=0.26) 强烈相关,与OR-WML (mR2=0.17),NAOR-FA (mR2=0.13) 和pRNFL (mR2=0.08) 适度相关.
- 多变量分析显示GCIPL和NAOR-FA是P100延迟的显著预测因素 (mR2=0.41). 在ON患者中,LGN体积与P100延迟显著相关 (mR2=-0.56).
结论:
- 在MS中,P100延迟受到视觉通路前后两部分损伤的影响.
- 在患有先前视神经炎的多发性硬化症患者中,LGN中突触水平的损伤可能导致延迟P100延迟.
- 这些发现支持VEP信号生成中的后阴影结构的作用,并突出了MS中独特的病理生理机制.
相关概念视频
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Visual Agnosia
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round end"...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...


