骨代谢生物标志物与成人和儿童化物暴露之间的相关性
Shuo Yang1, Shuiyuan Yu1, Yuhui Du1
1Department of Environmental Health, School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
概括
这项研究研究了化物暴露如何影响儿童和成人的骨代谢. 关键的生物标志物如骨质素 (OCN) 和β-CrossLaps (β-CTX) 与尿路化物水平有显著的相关性,表明化物.
科学领域:
- 环境健康 环境健康
- 骨代谢研究研究 骨代谢研究
- 毒理学 毒理学 毒理学
背景情况:
- 全球范围内,人们对增加的化物暴露及其对骨代谢的影响存在担忧.
- 骨代谢对化物暴露的精确相关性和敏感性仍在争论中.
- 高化物地区对公共卫生和骨完整性构成独特的挑战.
研究的目的:
- 研究尿液化物 (UF) 含量与儿童和成人各种骨代谢生物标志物之间的相关性.
- 确定敏感的骨代谢生物标志物,以评估不同年龄段的化物暴露影响.
- 探索化物对骨健康的剂量反应关系和潜在值影响.
主要方法:
- 这项横截面研究涉及549名儿童 (7-12岁) 和504名来自高化物地区的成年人.
- 使用电极测量尿液化物 (UF).
- 血清骨代谢生物标志物的分析,包括骨素 (OCN),骨酸酶 (BALP),副甲状腺激素 (PTH), (P5+), (Ca2+) 和β-CrossLaps (β-CTX) 使用回归,趋势测试和通用添加模型.
主要成果:
- 在儿童中,UF与血清OCN,PTH和BALP之间发现了显著的相关性,OCN显示了线性相关性.
- 在儿童中观察到UF与血清P5+,BALP和OCN之间的非线性剂量反应关系.
- 在成年人中,UF与β-CTX,P5+和Ca2+有显著的相关性,对Ca2+,P5+和β-CTX观察到非线性关系.
结论:
- 血清OCN,BALP和P5+被确定为暴露于化物的儿童骨代谢的敏感生物标志物.
- 血清β-CTX,P5+和Ca2+被提议作为对成年人化物暴露影响的敏感生物标志物.
- 该研究强调了特定于年龄和生物标志物的化物敏感性,为风险评估和监测策略提供了信息.
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