相关实验视频
Updated: Jul 1, 2025

10:35
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
18.2K
癌症老年人使用静止剂 - - 来自专门的老年瘤服务机构的经验
Darragh T O'Sullivan1, Darren J Walsh2, Caitriona Goggin1
1University Hospital Waterford, Waterford, Ireland.
Journal of geriatric oncology
|March 10, 2024
概括
在老年癌症患者中,使用他类药物很常见,即使是用于初级预防. 对于患有第四阶段癌症或接受初级预防的人来说,停止处方他类药物可能是合适的,因为生存益处有限.
科学领域:
- 老年瘤学 老年瘤学
- 预防心血管疾病 预防心血管疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 立方体治疗被广泛使用,使用越来越多,并扩大了适用范围.
- 在老年人中,特别是那些患有生命限制疾病的人中,停止使用他类药物的研究是有限的.
- 使用他类药物的初级预防需要长期治疗,以预防主要的心血管不良事件.
研究的目的:
- 为了确定使用他类药物在患有癌症的老年人中的流行率.
- 评估这种队列中,在初级预防与二级预防中使用他类药物的使用模式.
- 探索在老年瘤患者中降低他类药物处方的潜力.
主要方法:
- 从预期维护的老年瘤诊所患者数据库中回顾性数据收集.
- 数据包括患者人口统计,癌症类型和阶段,全身抗癌疗法 (SACT) 建议,并发症和整体存活率.
- 对于初级预防和第四期癌症患者,分别分析了类固醇药物治疗数据.
主要成果:
- 在研究的230名患者中,59%的患者被处方他类药物,其中58%用于初级预防.
- 40%的患者患有第四期癌症;其中63%的患者接受了他类药物治疗.
- 初级预防组的2.5年生存率为23%,第四阶段癌症组为16%.
结论:
- 类固醇药物治疗在患有癌症的老年人中普遍存在,包括患有晚期疾病和寿命有限的老年人.
- 这些发现表明,对于接受初级预防或患有第四阶段癌症的患者来说,降低他类药物的处方可能是合理的考虑.
- 需要进行进一步的研究,以制定明确的指导方针,在老年瘤学中停止使用他类药物.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K

