严重精神疾病中的认知和炎症异质性:将发现从血液转化为大脑
Linn Sofie Sæther1, Attila Szabo2, Ibrahim A Akkouh3
1Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
Brain, behavior, and immunity
|March 10, 2024
概括
精神分裂症和双相情感障碍的认知障碍与免疫失调有关. 在患有严重精神疾病的子组中,YKL-40可能作为认知功能的标记物,将外周炎症与大脑机制联系起来.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 认知障碍和免疫失调与精神分裂症 (SZ) 和双相情感障碍 (BD) 有关.
- 异质性和血液到大脑机制在理解这些联系方面存在挑战.
研究的目的:
- 确定与SZ和BD的认知领域相关的外围标记.
- 阐明异构的免疫认知模式.
- 评估iPSC衍生细胞中的标志物调节和血液和大脑样本中的RNA表达.
主要方法:
- 分析了1235个人的队列 (SZ,BD,健康对照).
- 评估了25个外围标记和9个认知领域.
- 利用从死后大脑样本 (CommonMind联盟) 获得的iPSC衍生细胞,微阵列和RNA测序.
主要成果:
- 根据认知领域和外围标记 (炎症,先天免疫力,细胞外矩阵重塑) 确定了跨诊断子组.
- 在SZ患者的iPSC衍生细胞中观察到YKL-40分泌变异.
- 在死后的大脑样本中,在高神经炎症子组中发现了失调的YKL-40基因表达.
结论:
- 周围炎症免疫活动与SZ和BD的认知障碍有关.
- YKL-40是严重精神疾病的子组认知功能的潜在标志物.
- 研究结果表明,外周炎症与影响认知的中央神经炎症过程之间存在联系.
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