西方饮食消费通过hippocampus acetylcholine信号失调来损害记忆功能
Anna M R Hayes1, Logan Tierno Lauer1, Alicia E Kao1
1Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Brain, behavior, and immunity
|March 10, 2024
概括
早期生活 西方饮食摄入导致持久的海马功能障碍和记忆缺陷,因为它破坏了乙胆信号传递. 健康饮食干预措施并没有扭转这些长期影响.
科学领域:
- 神经科学是一个神经科学.
- 营养神经科学 营养神经科学
- 发育神经科学的发展神经科学.
背景情况:
- 西方饮食 (WD) 的早期生活消费与记忆力受损有关,特别是依赖海马的功能.
- 长期持续的海马功能障碍可能是早期饮食侮辱的结果.
- 乙胆 (ACh) 信号失调是导致记忆障碍的已知因素.
研究的目的:
- 为了研究长期存在的海马体功能障碍背后的神经生物学机制,由早期生命WD引起.
- 建立一种动物模型来研究青少年和青少年WD对记忆和海马体功能的影响.
- 探索乙胆信号在WD引起的记忆缺陷中的作用.
主要方法:
- 在幼儿/青少年阶段,老鼠被食西方饮食 (食堂式) 或标准食.
- 在健康饮食干预之前和之后进行了行为和代谢评估.
- 用于检查海马体功能的蛋白质标记物,用于ACh释放的体内纤维光度,以及神经药理干预措施.
主要成果:
- 早期的WD消费导致持续的海马体依赖性记忆障碍,即使是在健康饮食干预之后.
- 在海马体中减少的囊泡性ACH载体蛋白水平表明,在WD养的老鼠中,长期减少了ACH度.
- 在WD养的老鼠中,在新鲜事物识别期间的ACh释放被破坏,并且高度预测记忆性能.
- 给予一个α7尼古丁性ACH受体激动剂在WD养的老鼠中挽救了记忆缺陷.
结论:
- 早期生活 西方饮食摄入导致海马体乙胆信号传递的长期干扰.
- 这种ACH信号失调是西方饮食相关记忆障碍的关键机制.
- 向乙胆信号通路可能为缓解早期饮食习惯导致的认知缺陷提供治疗潜力.
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