与脂肪肝相关的甲酸生物标志物组成:从流行病学和体内研究中获得的证据
Shucong Chen1, Hang Liu1, Yulian Sun2
1MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
The Science of the total environment
|March 10, 2024
概括
脂肪肝疾病改变了甲酸代谢,显示尿甲酸水平较低,但改变了患者的代谢物概况. 在老鼠中,脂肪肝延长了DEHP的排泄,并增加了关键的代谢酶.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢过程中的代谢.
背景情况:
- 酸盐是内分泌干扰剂,具有潜在的毒性风险.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个普遍存在的全球健康问题.
- 脂肪肝对污染物代谢的影响经常被忽视.
研究的目的:
- 调查脂肪肝对人类和动物模型中甲酸盐代谢的影响.
- 为了比较脂肪肝患者和健康人的尿液中的甲酸单 (mPAE) 度和概况.
- 为了检查饮食诱导的脂肪肝对二-2-乙烯基甲酸盐 (DEHP) 和肝酶活性在老鼠的代谢的影响.
主要方法:
- 分析了人类尿液样本以检测甲酸单 (mPAE) 度和成分.
- 雄性Wistar大鼠被食高脂肪饮食12周,以诱导脂肪肝.
- 给大鼠服用DEHP,并比较正常和脂肪肝组之间的DEHP,其代谢物 (mDEHP) 和肝酶 (CYP450,UGT1,CARE1) 的水平.
主要成果:
- 与健康人相比,脂肪肝患者的尿mPAE显著降低,但mDEHP中单-2-乙烯基甲酸盐 (mEH) 的比例较高.
- 在老鼠中,脂肪肝延长了DEHP的消除半衰期 (24.61小时与18.89小时).
- 在老鼠中脂肪肝增加了CYP450,CarE1和UGT1酶的肝脏含量.
结论:
- 脂肪肝疾病显著改变体内代谢和消除像DEHP这样的酸盐.
- 脂肪肝中肝脏代谢酶的升高表明异生菌有补偿性或改变的代谢途径.
- 这些发现对于在涉及不同人群的流行病学研究中进行准确的生物监测和暴露评估至关重要.
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