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Mas和pGCA受体的联合激活通过氧化/cGMP系统抑制Endothelin-1诱导的内皮功能障碍

Trupti Ghatage1, Sameer Singh2, Kalyaneswar Mandal2

  • 1Department of Pharmacy, Birla Institute of Technology and Sciences (BITS) Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad, Telangana 500078, India.

Biochimica et biophysica acta. Molecular basis of disease
|March 10, 2024
PubMed
概括

一种新型的双重作用 (DAP) 通过协同激活Mas和pGCA受体,在高血压大鼠中有效地恢复了大动脉内皮功能. 与洛萨坦相比,这种在减轻血管损伤和恢复血管度方面表现出更高的疗效.

关键词:
内皮质功能障碍 内皮质功能障碍末端蛋白 1 1 的情况.更多的受体受体.氧化氧化是什么?eNOS-依赖的血管松.的 pGCA 受体.

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