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来自Dioscotea opposita的一种多糖的结构特征和免疫调节活性

Pengyue Li¹, Yongshuai Jing², Xiaoyue Qiu³

¹College of Pharmacy, Hebei University of Chinese Medicine, 3 Xingyuan Road, Shijiazhuang 050200, China; Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, 3 Xingyuan Road, Shijiazhuang 050200, China.

International journal of biological macromolecules

|March 10, 2024

概括

迪奥斯科雷亚对立多糖 (DOP-2) 通过在细胞中增强氧化,IL-6和TNF-α来增强免疫功能. 这种天然化合物还可以改善小鼠的肠道健康和免疫器官功能.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
微生物学微生物学

背景情况:

神相对多糖 (DOP-2) 是具有潜在健康益处的生物活性化合物.
了解DOP-2的免疫调节机制对于其治疗应用至关重要.
肠道微生物群在调节免疫反应方面发挥着重要作用.

研究的目的:

用RAW264.7细胞在体外研究DOP-2的免疫调节作用.
评估DOP-2在免疫受损小鼠中的体内疗效.
阐明潜在的机制,包括对肠道微生物群和短链脂肪酸 (SCFA) 的影响.

主要方法:

在实验室测试中测量了用DOP-2治疗的RAW264.7细胞中的氧化 (NO),介质素-6 (IL-6) 和瘤亡因子-α (TNF-α).
实体研究涉及免疫功能低下的小鼠,接受DOP-2治疗,以评估体重,免疫器官指数和肠道微生物群组成.
在免疫抑制小鼠中分析SCFA的产生.

主要成果:

DOP-2显著增加了RAW264.7细胞的NO,IL-6和TNF-α分泌.
在免疫抑制小鼠中,DOP-2治疗恢复了体重和改善了免疫器官指数.
在体内,DOP-2促进了SCFA的产生,并调节了肠道微生物群的组成.

结论:

DOP-2通过增强细胞免疫反应,表现出显著的免疫调节作用.
在免疫受损模型中,DOP-2改善宿主免疫状态和肠道健康.
这些发现支持D. opposita多糖类作为免疫调节辅助剂的潜力.

关键词:

迪奥斯科里亚相反的对立免疫调节活性免疫调节活性聚糖类是多糖类的.净化净化净化净化结构性表征结构性表征

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