戒烟时间对肺癌死亡率的影响:系统性审查和元分析
Hongkun Lai1, Quanzhen Liu2, Qianxian Ye1
1National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, China; Guangzhou Medical University, Guangzhou 510180, China.
戒烟,尤其是早戒和长期戒烟,可以显著降低肺癌死亡率. 这种好处适用于一般的戒烟者和那些在诊断时戒烟的人.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 戒烟对于减少肺癌死亡率至关重要.
- 之前的研究表明,根据人口和戒烟持续时间,结果各不相同.
- 缺乏关于不同人群中戒烟持续时间和肺癌死亡率的清晰定量元分析.
研究的目的:
- 量化评估戒烟时间与肺癌死亡率之间的关联.
- 按人口群体分层分析:一般戒烟者和诊断前戒烟者.
- 为早期和持续戒烟的好处提供明确的证据.
主要方法:
- 在2023年2月之前,对四个主要的电子数据库进行系统的文献搜索.
- 包括报告肺癌存活率和戒烟持续时间的研究.
- 使用随机效应模型的元分析,与人口分层.
主要成果:
- 分析包括24项研究,涉及969560人.
- 对于一般戒烟者来说,死亡风险随着戒烟时间的延长而降低:<10年 (RR 0.64),10-20年 (RR 0.33),>20年 (RR 0.16).
- 在诊断前戒烟者中,1年后的生存期 (RR 0.80) 和5年后的生存期 (RR 0.85) 显示死亡风险降低.
结论:
- 早期和更长时间的戒烟与肺癌死亡率的降低密切相关.
- 戒烟的好处是显而易见的,无论与诊断相比的时间如何.
- 这些发现强调了戒烟对肺癌生存的关键重要性.
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