[2型糖尿病患者的体重变化和糖尿病病风险之间的相关性]
Y Q Fang1, W W Wang2, H H Liu3
1International School of Nursing, Hainan Medical University, Haikou 571199, China.
Zhonghua yi xue za zhi
|March 10, 2024
概括
体重变化,包括BMI-VIM,BMI-ASV,BMI-CV和BMI-SD,与2型糖尿病患者患糖尿病病 (DKD) 的风险更高有关. 这一发现凸显了监测体重波动对于预防DKD的重要性.
科学领域:
- 内分泌学和新陈代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 体重变化,不仅仅是体重指数 (BMI),可能会影响DKD风险.
- 了解不同体重变化指标的影响对于对T2DM患者的DKD风险评估至关重要.
研究的目的:
- 研究各种体重变化指数与糖尿病病 (DKD) 发病率之间的关联.
- 为了评估BMI变异性独立于平均值 (BMI-VIM) 的预测值,平均年平均平方连续差异 (BMI-ASV),变化系数 (BMI-CV) 和T2DM患者DKD风险的标准偏差 (BMI-SD).
主要方法:
- 对2,180名没有DKD的T2DM患者进行了回顾性队列研究.
- 计算四个体重变化指数 (BMI-VIM,BMI-ASV,BMI-CV,BMI-SD) 基于随访期间每年的BMI测量.
- 考克斯比例危险回归模型被用于分析体重变化指数和DKD发病率之间的关系,并对肥胖状况进行亚组分析.
主要成果:
- 在平均随访时间为4.55年后,904名患者患上了DKD.
- 较高的BMI-VIM,BMI-ASV,BMI-CV和BMI-SD水平与DKD风险增加有显著的关联.
- 在BMI-ASV的最高四分位数中,DKD的风险在BMI-ASV的最低四分位数中增加了高达51.1%,在肥胖和非肥胖子组中观察到其他变化指数的类似趋势.
结论:
- 按BMI-VIM,BMI-ASV,BMI-CV和BMI-SD测量的体重变异性增加,与2型糖尿病患者 (T2DM) 患糖尿病病 (DKD) 的更高风险独立相关.
- 这些发现表明,监测体重波动可能是预测和潜在地预防T2DM患者的DKD的一个重要策略.
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