使用脂质比率来预测年轻人血管目标器官损伤的情况
Sarah E Henson1, Elaine M Urbina1
1Cincinnati Children's Hospital Medical Center & the University of Cincinnati, USA (Drs Henson and Urbina).
Journal of clinical lipidology
|March 10, 2024
概括
高脂质比率,特别是甘油三与高血糖-C (TG/HDL-C),表明青少年和年轻人的动脉硬性增加. 早期识别TG/HDL-C升高可能会预防未来的心血管疾病.
科学领域:
- 心血管科学 心血管科学
- 儿科内分泌学 儿科内分泌学
- 脂质学 脂质学是指脂质学.
背景情况:
- 升高的脂质水平是早期动脉样硬化的确立危险因素.
- 脂质比率正在成为心血管变化和动脉质胆固醇的强有力的预测指标.
- 肥胖年轻人或2型糖尿病患者的风险分层可以通过脂质比率来提高.
研究的目的:
- 为了调查脂质比是否能在青少年和年轻成年人中发现动脉结构和硬度异常.
- 评估脂质比率对年轻人血管变化的预测价值.
- 为了确定最有效的脂质比率来识别血管异常.
主要方法:
- 762名10-24岁的个人接受了实验室,人体测量,血压,动脉内膜介质厚度和动脉硬度评估.
- 研究对象根据脂质比率和非高密度脂蛋白胆固醇 (HDL-C) 分为三层.
- 使用ANOVA分析了血管结果,一般线性模型和相关性分析检查了脂质标记物,血管测量和低密度脂蛋白 (LDL) 颗粒特征.
主要成果:
- 在所有脂质比分三位体和非HDL-C中观察到动脉厚度和硬度的逐渐增加.
- 甘油三和高血糖-C (TG/HDL-C) 比率独立预测了动脉厚度和硬度,即使在调整其他心血管风险因素之后.
- TG/HDL-C与动脉硬性和小而密集的LDL颗粒的相关性最强.
结论:
- 增加的动脉硬性在年轻人中普遍存在,他们的脂质比率较高,TG/HDL-C是血管变化的最一致的指标.
- 在这个人群中识别高TG/HDL-C可能会促进早期干预,以预防动脉样硬化心血管疾病.
- 脂质比率,特别是TG/HDL-C,是青少年和年轻人早期血管风险评估的有价值标志物.
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